Escola Paulista de Medicina
Postgraduate Program in Pharmacology

NATURAL PRODUCTS, DRUG DEVELOPMENT AND BIOMARKERS:Projects

Projects of the NATURAL PRODUCTS, DRUG DEVELOPMENT AND BIOMARKERS Research Line of the Postgraduate Program in Pharmacology:

PHARMACOGENOMICS AND BIOMARKERS

PHARMACOGENOMICS AND BIOMARKERS

For the first, we focus efforts on investigating new molecular biomarkers of susceptibility to pharmacological treatments. In addition, we list pharmacogenomic biomarkers and implement randomized clinical projects in order to assess the effectiveness and cost-effectiveness of the approach, a pioneer in our country. In the scenario of iron metabolism, we focus on genetic analysis in patients with hemochromatosis, use of iron chelators, sequencing of new generation and measurement of hepcidin (iron hormone and with possible implications for cancers). The main impacts were: collaborations with the main researchers in the world and in our country in these fields.

Professor: Paulo Caleb Junior de Lima Santos

NATURAL PRODUCTS, DRUG DEVELOPMENT AND IDENTIFICATION OF BIOMARKERS IN MENTAL DISORDERS

NATURAL PRODUCTS, DRUG DEVELOPMENT AND IDENTIFICATION OF BIOMARKERS IN MENTAL DISORDERS

Natural products and drug development studies are focused on the evaluation of a rattlesnake toxin with antimicrobial and antitumor activities, and with effects on metabolism; in addition, we evaluate its use as a possible carrier of drugs and as a theranostic agent (therapy + diagnosis) for application in several areas, while in the mental disorders field, we investigate the oligopeptidases and peptidergic pathways that may be involved in the etiology and/or pathophysiology of these disorders, with focus on schizophrenia and/or bipolar disorder and in the search for diagnosis biomarkers. For further information access https://farmolab.unifesp.br/.

Professor: Mirian Akemi Furuie Hayashi

DRUG TOXICOLOGICAL RESEARCH OF NEW COMPOUNDS WITH ANTITUMOR ACTIVITY AND IDENTIFICATION OF NEW THERAPEUTIC APPLICATIONS FOR OLD DRUGS WITHIN ONCOLOGY

DRUG TOXICOLOGICAL RESEARCH OF NEW COMPOUNDS WITH ANTITUMOR ACTIVITY AND IDENTIFICATION OF NEW THERAPEUTIC APPLICATIONS FOR OLD DRUGS WITHIN ONCOLOGY

Our goal is to study cancer in various aspects of its treatment, such as the development of new drugs, new therapeutic applications for existing drugs and also the pharmacological activity of plant extracts. We focus our studies in understanding the molecular mechanisms controlling cell death and autophagy, processes that are important for tumor development. We are also interested in studies about cachexia and sarcopenia, processes involved in the response of cancer patients to pharmacological therapy. We have important collaborations in Brazil and abroad. Financial supports: FAPESP, CNPq e CAPES.

Professor: Claudia Bincoletto Trindade

CIRCULATING TUMOR CELLS AS SOLID TUMOR BIOMARKERS

CIRCULATING TUMOR CELLS AS SOLID TUMOR BIOMARKERS

Circulating Tumor Cells (CTCs) can indicate early on the development of a tumor, its evolution and the acquisition of resistance to a given treatment. Thus, they can be used as response markers to certain drugs. We have some results with TYMS (thymidylate synthase) and MRP-1 (Multidrug Resistance Protein-1) in metastatic colorectal cancer and HER-2 in gastric cancer. Our aim is to expand our approach to phase II clinical trials, in which CTCs can be used as a tool for defining clinical management.

Professor: Ludmilla Thomé Domingos Chinen

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