Escola Paulista de Medicina
Postgraduate Program in Pharmacology

Miriam G. Jasiulionis

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Research focus: Sustained stress, epigenetic marks, malignant transformation and melanoma progression

Undergraduate degree obtained in Biological Sciences at Escola Paulista de Medicina (1990), MSc (1993) and PhD (1997) in Microbiology and Immunology at Escola Paulista de Medicina. Now, is Associate professor at Pharmacology Department, Universidade Federal de São Paulo. Have experience in Cellular and Molecular Biology of Cancer, and a special interest in the relation among oxidative stress, epigenetic alterations and malignant transformation and melanoma progression.

We have investigated the role of epigenetic alterations in the relationship between sustained stressful conditions and malignant transformation, especially in melanocytes. Increased levels of reactive oxygen species (ROS), caused for example by chronic inflammation, aging or UV radiation, might be responsible for the establishment of abnormal epigenetic marks, and contribute to melanoma genesis. In this context, we have investigated how cellular stress induces epigenetic alterations (DNA methylation, histone modifications, and microRNAs) and its contribution to the acquisition of a malignant phenotype. In this way, the study of the relation among sustained stress, aberrant epigenetic marks and malignant transformation may contribute to a better comprehension of mechanisms involved in cancer genesis and thus open new avenues to the development of novel preventive and therapeutic approaches.

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